Gene Regulation and in Vivo Function of Liver Transcription Factors
نویسندگان
چکیده
PHYSIOLOGIC ROLE OF HNF-3 IN MOUSE LIVER AND PANCREATIC FUNCTION 63 Transcriptional Activity of the HNF-3 Proteins 63 Potential HNF-3 Target Genes in the Liver 63 Cellular Expression Pattern of HNF-3 Isoforms in Mouse Development and Adult Organs 63 The HNF-3β Gene Is Critical for Early Embryonic Development 65 Elevated Levels of HNF-3β in Mouse Hepatocytes Influence Expression of Genes Involved in Bile Acid and Glucose Homeostasis 65 Targeted Disruption of the Mouse Hnf3 Genes Demonstrates that They Regulate Expression of Genes Required for Glucose Homeostasis 65
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